研究者プロフィール
物質･材料･エネルギー･環境スマートラボ Materials Science / Energy / Environment Smart Lab
KUMAR Sanjay KUMAR Sanjay 助教
- 研究テーマ
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- Synthesis of natural product analogues for biological evaluation
- Synthesis of macromolecules from natural resources
- Synthesis of prodrugs and fabricate into nano prodrugs
- Post polymerization modification
- 研究キーワード
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Medicinal chemistry, Organic chemistry, Nano Prodrugs, Natural
Products, Polymer Chemistry - 研究概要
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Synthesis and fabrication of nano prodrugs for chemotherapy
Novel prodrugs were developed based on a chemical structure that allows releasing the anticancer agent specifically in cancer cells. The prodrugs were fabricated into nanoparticles without the use of nanocarriers or PEG. These nano-prodrugs (NPDs), which consist of two molecules of the anticancer agent SN-38 connected via a linker with a S-S bond, are stable toward hydrolysis by carboxylesterase, and selectively release SN-38 in environments with high concentrations of GSH such as cancer cells.Methyl dihydrojasmonate and methyl (5-methylidene-4-oxocyclopent-2- en-1-yl)acetate were synthesized from 4-hydroxy-2- (hydroxymethyl)cyclopentenone, which was obtained from D-Glucose. The reaction condition of the key reaction, Johnson-Claisen rearrangement, was optimized to get the maximum yield of an intermediate, methyl 2-(2-methylene-3-oxo-5- ((triisopropylsilyl)oxy)cyclopentyl)acetate. Common intermediate was used for the synthesis of both methyl dihydrojasmonate and methyl (5- methylidene-4-oxocyclopent-2-en-1-yl) acetate.
